Fertility – Men

Medications being studied as a potential treatment for secondary hypogonadism and male infertility. It works by stimulating the body’s natural production of testosterone and may help to improve sperm production and quality. Example: Here is how Enclomiphene works to potentially improve male fertility: *Mechanism of Action: Enclomiphene is a selective estrogen receptor modulator (SERM) that works by blocking estrogen receptors in the hypothalamus and pituitary gland, disrupting the negative feedback loop that normally suppresses LH and FSH production. This leads to an increase in LH and FSH release, which then stimulate the testes to produce more testosterone. The increased LH stimulates Leydig cells in the testes to make testosterone, and the elevated FSH levels support spermatogenesis (sperm production).