How can enclomiphene citrate help you?

Enclomiphene citrate helps raise blood testosterone levels and preserve sperm counts in hypo-gonadal men.

In the context of male infertility, clomiphene has been used off-label to treat secondary hypogonadism for quite some time. The androgenic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are increased in response to enclomiphene citrate, which increases serum testosterone levels.

For males for whom testosterone replacement therapy is not an option, enclomiphene citrate may have a role in treating testosterone insufficiency without negatively impacting fertility.

Since enclomiphene citrate is suggested for treating some men with secondary hypogonadism, especially those whose condition is brought on by dysfunctional but reversible hypothalamic/pituitary activity. These males typically have low or abnormally normal gonadotropin levels and low total testosterone.

However, enclomiphene citrate is not recommended for treating secondary hypogonadism caused by conditions such as pituitary tumors, craniopharyngiomas, hemochromatosis, or congenital GnRH deficiency in men.

Enclomiphene citrate for male hypogonadism

In males with hypogonadism, the following symptoms are usually present:

  • Lower serum testosterone.
  • Difficulty concentrating.
  • Diminished libido.
  • Disturbed sleep.
  • Erectile dysfunction.
  • Fatigue and lethargy.
  • Lean body mass and muscle loss.
  • Weight gain.

Dosage considerations section:

Total T levels in hypogonadal men were considerably enhanced with 12.5 mg and 25 mg enclomiphene citrate, with an effect size equivalent to topical testosterone. Treatment with enclomiphene citrate was also associated with elevated LH and FSH levels.


Long-term secondary hypogonadism can result in health problems that are more common in elderly adults. Secondary hypogonadism in men has been linked to increased mortality, obesity, metabolic syndrome, and/or insulin resistance/type II diabetes.

Comparison between testosterone and enclomiphene citrate.

Its primary purpose in creation and evaluation was to stimulate ovulation and, by extension, improve female fertility.

The end outcome is a slight rise in testosterone levels in males without affecting their ability to have children. With Comid, we can usually elevate T levels by 100%. There could even be a 200% rise in rare circumstances.

How long does it take for enclomiphene citrate to start working?

Changes in serum LH pharmacodynamics after treatment with enclomiphene citrate compared to transdermal testosterone.

The effectiveness of treatments is evaluated over 24 hours, with the effects of both the starting and maintenance doses after 6 weeks of treatment being compared.

The steady-state concentration was highest at 25 mg/day and was not dose-dependent. Enclomiphene citrate’s benefits persisted with once-daily administration. As a result, enclomiphene citrate raises both total and free testosterone without causing an excessive rise in DHT.

Can enclomiphene citrate help men have more sperm?

With eclomiphene citrate, both testosterone and sperm count improved. Changes in LH and FSH levels simultaneously indicate that the hypothalamic-pituitary-testicular axis has been reset, allowing for average testosterone production and a return to pre-declined sperm counts.


Serums were raised in response to enclomiphene citrate, although there was no correlation between the drug’s peak concentration and the maximum LH or total testosterone levels.

Consistently, enclomiphene citrate elevated LH and FSH levels above the normal range and brought total serum testosterone levels within the normal range. The duration of the LH and total testosterone increase after therapy ended was at least a week. To get online consultation, signups at